Product Name: Tetramethylammonium Acetate
Chemical Formula: C6H15NO2
CAS Number: 10424-65-4
Synonyms: TMAA, Acetic acid tetramethylammonium salt
Recommended Use: Laboratory reagent, organic synthesis, ion-pairing agent, chromatography additive
Supplier Information: Company name, address, and emergency telephone contact
Emergency Phone: Available 24 hours for chemical incidents
Classification: Acute oral toxicity (Category 4), Skin and eye irritant (Category 2), Specific target organ toxicity-single exposure (Category 3)
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, possible respiratory tract irritation
Pictograms: Exclamation mark (GHS07)
Signal Word: Warning
Precautionary Statements: Wash face, hands, and exposed skin thoroughly after handling, avoid breathing dust or vapors, use only outdoors or in well-ventilated areas, wear protective gloves/eye protection
Symptoms of Exposure: Sore throat, abdominal pain, headache, skin redness or blisters, eye redness, watering, breathing difficulties
Substance: Tetramethylammonium Acetate
Chemical Formula: C6H15NO2
CAS Number: 10424-65-4
Concentration: 98 – 100%
Impurities: Trace methylamine, acetic acid (under 2%)
Ingredient Type: Single substance
Inhalation: Move to fresh air, keep at rest in a position comfortable for breathing, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, immediately wash with plenty of soap and water for at least fifteen minutes, consult a physician for persistent irritation
Eye Contact: Remove contact lenses, immediately flush eyes with plenty of water for at least fifteen minutes, keep eyelids apart, seek medical attention
Ingestion: Rinse mouth thoroughly, never give anything by mouth to an unconscious person, seek immediate medical attention
Most Important Symptoms/Effects: Irritation, pain, cough, possible respiratory distress, gastrointestinal upset
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: None known for product, but avoid high-pressure water jets
Specific Hazards: Emits toxic fumes including nitrogen oxides and carbon monoxide under fire conditions
Firefighter Protection: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Cool fire-exposed containers with water, prevent runoff from entering drains or open water
Explosion Data: Not sensitive to impact or static discharge under normal conditions
Personal Precautions: Evacuate area, ventilate, wear appropriate personal protective equipment including gloves, eye protection, and respirator
Environmental Precautions: Prevent entry into drains, sewers, and public waterways
Spill Cleanup Methods: Contain spillage, absorb with inert material such as dry sand or vermiculite, collect for disposal in accordance with regulations
Decontamination: Wash spill area with water after material pickup
Handling: Use only in well-ventilated areas, avoid contact with skin and eyes, do not breathe vapors or dust, handle in accordance with good chemical hygiene practices
Storage: Store in tightly closed original container, keep in cool, dry, well-ventilated location, segregate from acids, oxidizers, and incompatible materials
Special Requirements: Store away from direct sunlight, heat sources, and moisture
Incompatibilities: Strong acids, oxidizers, acid chlorides, anhydrides
Exposure Limits: No established OSHA or ACGIH limits; minimize exposure following good laboratory practice
Engineering Controls: Laboratory fume hood, eye-wash/safety shower, mechanical ventilation
Personal Protective Equipment: Safety glasses or goggles, chemical-resistant gloves (nitrile recommended), lab coat or protective clothing, appropriate respiratory protection when airborne concentrations exceed threshold
Hygiene Measures: Wash hands before breaks or after handling, do not eat or drink near the substance, avoid inhaling dust or vapor
Appearance: White crystalline or powder solid
Odor: Mild, characteristic (ammoniacal)
Odor Threshold: Not determined
Molecular Weight: 133.19 g/mol
pH (1% solution): 8-9 (slightly basic)
Melting Point: 170-175°C (decomposes)
Boiling Point: Decomposes
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not applicable (solid)
Flammability: Not combustible
Vapor Pressure: Negligible at room temperature
Solubility: Freely soluble in water, methanol, ethanol
Partition Coefficient: Not available
Vapor Density: Not applicable
Relative Density: 1.020 – 1.060 g/cm³
Viscosity: Not applicable
Chemical Stability: Stable under recommended conditions, sensitive to moisture and prolonged heat
Hazardous Polymerization: Not known to occur
Reactivity: Reacts with strong oxidizers and strong acids, may release toxic gases
Decomposition Products: Methylamine, nitrogen oxides, carbon oxides when heated strongly
Incompatible Materials: Acids, oxidizing agents, acid chlorides, anhydrides
Potential Routes of Exposure: Inhalation, ocular, dermal, ingestion
Acute Toxicity: LD50 (oral, rat): estimated 200-500 mg/kg, LD50 (dermal, rabbit): data not available
Skin Corrosion/Irritation: Causes moderate skin irritation
Eye Damage/Irritation: Mild to severe irritation, possible corneal injury
Respiratory Sensitization: May cause upper respiratory tract irritation
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Reproductive/Developmental Toxicity: No information available
Target Organ Effects: Central nervous system, liver, kidneys at high doses
Other Information: Chronic exposure data not extensive; may aggravate pre-existing conditions
Toxicity to Aquatic Organisms: May be harmful to aquatic life, EC50/LC50 values not well established
Persistence and Degradability: Limited data; assumed to be biodegradable under environmental conditions
Bioaccumulation Potential: Low expected due to water solubility
Mobility in Soil: High mobility in water due to solubility
Other Adverse Effects: Avoid release to environment, chemical runoff may affect pH of water bodies
Disposal Methods: Dispose through properly licensed chemical waste disposal contractors
Product Disposal: Follow local, regional, national, and international laws; do not release into drains or environment
Contaminated Packaging: Triple rinse, puncture, and deliver to authorized recycler or hazardous waste facility
Special Precautions: Avoid contact with incompatible chemicals during disposal
UN Number: Not regulated under UN transport codes for most jurisdictions
Proper Shipping Name: Tetramethylammonium Acetate
Hazard Class: Not classified as dangerous goods for transport
Packing Group: Not assigned
Marine Pollutant: No
Transport Precautions: Protect from moisture, store in tightly sealed containers, keep upright
Special Transport Notes: Comply with all regulatory requirements during loading, transit, and handover
OSHA Status: Not listed as hazardous under OSHA Hazard Communication Standard
TSCA Status: Listed in the United States TSCA inventory
SARA Title III: Not subject to SARA Section 302, 304, 313 reporting
California Proposition 65: Not listed
DSL (Canada): Listed or exempt
WHMIS (Canada): Classified as D2B (Toxic Material Causing Other Toxic Effects)
European Union: Covered by REACH, not classified as a major hazard, safety data available for workplace use
Inventory Status: Included in relevant governmental chemical inventories worldwide
