Product Name: 18-Crown-6
Chemical Name: 1,4,7,10,13,16-Hexaoxacyclooctadecane
Synonyms: Crown Ether 18-6, 1,4,7,10,13,16-hexoxacyclooctadecane
CAS Number: 17455-13-9
EC Number: 241-475-6
Recommended Use: Complexing agent for alkali metals, laboratory chemicals
Supplier: Chemical supply labs, university stockrooms, specialty manufacturers
Emergency Contact: Local poison control center, emergency medical services
GHS Classification: Eye Irritation Category 2, Skin Sensitizer Category 1, Acute Toxicity Oral Category 4
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, causes serious eye irritation, harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, wear protective gloves, avoid contact with eyes and skin
Potential Health Effects: Irritation to skin, eyes, possible respiratory irritation from dust ingestion may lead to nausea, headache
Environmental Effects: May persist in aquatic environments, toxic to certain aquatic organisms in laboratory studies
Chemical Formula: C12H24O6
Main Ingredient: 18-Crown-6 (purity at least 98%)
Impurities: Mostly water, traces of other crown ethers, minor byproducts from production
Concentration: Greater than 97% by weight for most reagent and technical grades
General Guidance: Remove person from exposure, seek medical attention when symptoms are troubling
Inhalation: Move to fresh air, give oxygen if breathing is difficult, consult doctor for persistent symptoms
Skin Contact: Rinse skin with soap and water for several minutes, remove contaminated clothing
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, hold eyelids open, seek immediate medical attention
Ingestion: Rinse mouth, do not induce vomiting, provide water to drink if victim is conscious, get medical advice immediately
Suitable Extinguishing Media: Use dry chemical, CO2, or foam; water spray for larger fires
Special Hazards: Emits toxic fumes under fire conditions, including carbon oxides
Fire-Fighter Protection: Use full-body firefighting suit, self-contained breathing apparatus
Further Information: Cool exposed containers with water spray to prevent rupture
Combustion Products: Smoke, carbon dioxide, carbon monoxide, potential traces of formaldehyde on decomposition
Personal Precautions: Ventilate area, avoid breathing dust, wear gloves and goggles
Environmental Precautions: Prevent runoff into drains, sewers, or waterways
Spill Containment: Sweep up and place in a suitable, labeled, sealed container for disposal
Clean-Up Methods: Large spills may require moistening with water to reduce dust, evacuate area as needed
Handling: Avoid prolonged or repeated exposure, keep containers tightly closed, use in a chemical fume hood
Storage Conditions: Store at room temperature or below, protect from moisture, store in a cool, dry, well-ventilated location
Incompatible Substances: Strong oxidizing agents, strong acids, certain alkali metals, avoid exposure to open flames
Hygiene: Wash hands and exposed skin thoroughly after handling, remove contaminated clothing before breaks
Exposure Limits: No specific occupational exposure limits established for 18-Crown-6 by OSHA, ACGIH
Engineering Controls: Use with local exhaust ventilation or in a chemical fume hood to minimize dust exposure
Respiratory Protection: Dust mask or respirator if engineering controls are insufficient
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Chemical-resistant gloves, lab coat, closed-toe shoes
Environmental Controls: Avoid release to the environment, follow local and federal regulations for emissions
Appearance: White crystalline solid or powder
Odor: Odorless or faint ethereal odor
Molecular Weight: 264.32 g/mol
Melting Point: 38-42 °C
Boiling Point: Decomposes before boiling at atmospheric pressure
Solubility: Soluble in water, ethanol, methanol, chloroform, ether
Partition Coefficient (log Kow): 0.2 (estimated)
Vapor Pressure: Negligible at room temperature
pH: Not applicable
Flash Point: > 100°C
Flammability: Not highly flammable, but combustible if exposed to open flame
Chemical Stability: Stable under recommended storage conditions; avoid long exposure to air and moisture
Hazardous Reactions: No dangerous polymerization or hazardous reactions expected in normal use
Conditions to Avoid: Avoid extreme heat, open flame, high humidity
Incompatible Materials: Strong oxidizers, strong acids, reactive alkali metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly trace formaldehyde on strong heating
Acute Toxicity: Oral LD50 (rat) 670 mg/kg, data from laboratory studies; lower toxicity by skin or inhalation
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Irritation to eyes and skin, headache, dizziness, nausea, allergic response in sensitized individuals
Chronic Effects: No long-term studies in humans, but animal studies report kidney and liver changes at high doses
Mutagenicity: Not classified as mutagenic in standard bacterial or animal tests
Carcinogenicity: Not listed by IARC, NTP, ACGIH, or OSHA as a carcinogen
Reproductive Toxicity: No known reproductive toxicity reported in animals or humans
Aquatic Toxicity: Not expected to be highly toxic in aquatic environments, but toxic to some aquatic organisms at very high concentration
Biodegradability: Limited biodegradability; persists in certain water or soil environments
Bioaccumulation: Potential for low-level bioaccumulation; log Kow suggests some potential uptake
Mobility in Soil: High water solubility leads to possible mobility through soil; may reach groundwater under some circumstances
Other Adverse Effects: No known damage to ozone layer; may affect water quality in sensitive areas
Disposal Methods: Incinerate in a chemical waste facility equipped for halogenated waste or landfill as hazardous waste where permitted
Container Disposal: Triple rinse, puncture, and dispose of container according to local regulations
Contaminated Packaging: Treat the same as pure chemical for hazardous waste disposal
Disposal Regulations: Follow national, state, and local requirements for environmental protection during disposal
UN Number: Not classified as dangerous goods for transport by road, air, or sea
Proper Shipping Name: 18-Crown-6
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Prevent release to environment during transport, keep container sealed and dry
US TSCA Status: Listed in the Toxic Substances Control Act inventory
DSL (Canada): Listed
REACH (EU): Registration status available for quantities over one ton/year, chemical safety report required by some suppliers
Other International Regulations: No significant restrictions reported in key markets; users subject to workplace safety regulations where applicable
Label Requirements: Conforms to hazard communication guidelines, include hazard statements and pictograms as per GHS classification
